Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1207
Protein Name
Aquaporin Z
Gene Name
aqpZ; PP_4282
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Length
230 amino acids
AlphaFoldDB
AF-Q88F17-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MSLGKRMGAELIGTFWLVLGGCGSAVLAASSPLGIGVLGVAFAFGLTVLTMAFAIGHISGCHLNPAVSFGLVVGGRFPAKELLPYVIAQVIGAILAAGVIYLIASGKAGFELSAGLASNGYADHSPGGYTLGAGFVSEVVMTAMFLVVIMGATDARAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGPALFVGGWALQQLWLFWVAPLIGAAIGGALYRGLAKEP
PDB Structures
Ligand Binding
Binding Site
SITE 22: "Involved in tetramerization or stability of the tetramer"; SITE 44: "Selectivity filter"; SITE 174: "Selectivity filter"; SITE 183: "Selectivity filter"; SITE 189: "Selectivity filter"
Disease
Location
DOI ID
10.1046/j.1462-2920.2002.00366.x
RefSeq
NP_746398.1